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标题：A Research Standard for Human Serum Immunoglobulins IgG, IgA and IgM
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作者：D. S. Rowe ; S. G. Anderson ; B. Grab 等
期刊名称：Bulletin of the World Health Organization
印刷版ISSN：0042-9686
出版年度：1970
卷号：42
期号：4
页码：535-552
语种：English
出版社：World Health Organisation
摘要：A pooled human serum, partly diluted, has been distributed into ampoules and freeze-dried in several batches. The freeze-dried material has been examined in an international collaborative assay and certain properties have also been estimated in individual laboratories. On the basis of these tests this material was considered to be suitable for use as a standard for the estimation of IgG, IgA and IgM for clinical purposes using the single-radial-diffusion or similar techniques. Greater uniformity of results than is obtained at present should be achieved if this material were in general use. Estimates of immunoglobulins from different laboratories using this material as a standard showed small but significant variability. This variability was probably related to the heterogeneity of immunoglobulins and of antisera, and it limits the precision of immunoglobulin estimations by techniques at present in use. Batches of this material have been distributed to various centres. 67/68 has been established as the British research standard for human serum immunoglobulins IgG, IgA and IgM for which the unit of potency is defined as the activity present in 0.8147 mg of dry powder. The average activity per ampoule of 67/86 is 100 units of IgG, IgA and IgM. The average activities of other related preparations have been estimated. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.5M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 535 536 537 538 538-1 538-2 539 540 541 542 543 544 545 546 547 548 549 550 551 552