文章基本信息

标题：The International Standard for Anti-Smallpox Serum
本地全文：下载
作者：S. G. Anderson ; Joyce Skegg
期刊名称：Bulletin of the World Health Organization
印刷版ISSN：0042-9686
出版年度：1970
卷号：42
期号：4
页码：515-522
语种：English
出版社：World Health Organisation
摘要：At the request of the WHO Expert Committee on Biological Standardization, the National Institute for Medical Research, London, obtained 63 samples of convalescent human plasma from patients recovering from smallpox. The sera were pooled and distributed into ampoules and freeze-dried. The freeze-dried material was examined in 11 laboratories in 6 countries in an international collaborative assay during 1964 and 1965. The results from 10 laboratories were more or less consistent, but relative potencies in terms of the proposed international standard estimated by one of the laboratories were exceptionally low. Since this laboratory used a strain of virus different from that used in all the other laboratories, it was suspected that antigenic properties or avidity of the virus might have caused the divergence of results; this is being investigated. After considering the report of the international collaborative assay, the WHO Expert Committee on Biological Standardization established the material as the International Standard for Anti-Smallpox Serum, and a unitage was assigned so that 1 International Unit of activity was contained in 0.08416 mg, and each ampoule contains (on average) 1000 IU of activity. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (943K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 515 516 517 518 519 520 521 522