摘要：The replacement of Freund's adjuvant by a possible safe adjuvant for effective immunization of owl monkeys ( Aotus trivirgatus griseimembra ) against a human malaria parasite, Plasmodium falciparum , has been investigated. Experiments involved the use of two synthetic adjuvants: MDP ( N -acetylmuramyl-L-alanyl-D-isoglutamine) and stearoyl-MDP (6- O -stearoyl- N -acetylmuramyl-L-alanyl-D-isoglutamine). In both cases, P. falciparum merozoites obtained through short-term in vitro cultivation were used as antigen. MPD was used as adjuvant in 5 owl monkeys; 2 control monkeys died and of the 3 experimental monkeys only 1 survived. In contrast, in another experiment where stearoyl-MDP was used as adjuvant, there was 100% protection of 4 immunized monkeys against a challenge with the homologous strain of P. falciparum. The results of the second experiment are encouraging for the development of an effective and safe vaccine for human malaria. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (719K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 199 200 201 202 203
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