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标题：Analysis of antigenic variation in equine 2 influenza A viruses
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作者：V. S. Hinshaw ; C. W. Naeve ; R. G. Webster 等
期刊名称：Bulletin of the World Health Organization
印刷版ISSN：0042-9686
出版年度：1983
卷号：61
期号：1
页码：153-158
语种：English
出版社：World Health Organisation
摘要：Influenza outbreaks involving viruses of the H3N8 subtype (equine 2) often occur in vaccinated horses. For this reason, a series of influenza viruses of the H3N8 subtype were examined to determine if antigenic variation could be detected in isolates during the period 1963-81. Antigenic analyses with post-infection ferret sera and monoclonal antibodies showed that the haemagglutinins of recent isolates were antigenically distinguishable from the prototype A/eq/Miami/1/63 and that antigenically distinguishable groups of equine 2 viruses co-circulate in the horse population. Based on these studies, it is recommended that a recent equine strain, A/equine/Fontainebleu/1/79 or A/equine/Kentucky/1/81, serve as an additional prototype strain for this subtype. Antigenic variation in equine 2 viruses may be of epidemiological significance, yet the overall conservation of these strains makes it unlikely that vaccine failures can be attributed solely to antigenic changes in these viruses. A sufficiently potent vaccine, containing a current representative of the most prevalent equine 2 strain, may improve the protection afforded by equine vaccines. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (742K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 153 154 155 156 157 158