文章基本信息

标题：A double-blind clinical trial of a combination of mefloquine, sulfadoxine and pyrimethamine in symptomatic falciparum malaria
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作者：J. M. Kofi Ekue ; O. O. Simooya ; U. K. Sheth 等
期刊名称：Bulletin of the World Health Organization
印刷版ISSN：0042-9686
出版年度：1985
卷号：63
期号：2
页码：339-343
语种：English
出版社：World Health Organisation
摘要：Fansimef is a combination of 250 mg of mefloquine, 500 mg of sulfadoxine, and 25 mg of pyrimethamine per tablet. A total of 150 adult male Zambian patients who had symptomatic Plasmodium falciparum parasitaemia were treated in a double-blind randomized fashion with either one, two or three tablets of Fansimef. All patients in the three treatment groups showed an S-type response. The rates of clearance of parasitaemia and fever were similar in all treatment groups. Tolerance was good at all dose levels. The main side-effects were abdominal discomfort, weakness and lassitude, dizziness, and pruritus, but these were mild, transient and required no specific treatment. Vomiting occurred only in 4% of patients given the highest dose of three tablets. The results of various haematological and biochemical investigations and urinalysis were not adversely altered by the administration of Fansimef. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (606K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 339 340 341 342 343