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标题：Defined Plasmodium falciparum antigens in malaria serology
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作者：M. S. Gabra ; D. Grossiord ; L. H. Perrin 等
期刊名称：Bulletin of the World Health Organization
印刷版ISSN：0042-9686
出版年度：1986
卷号：64
期号：6
页码：889-896
语种：English
出版社：World Health Organisation
摘要：The study evaluates three enzyme-linked immunosorbent assays (ELISA) of malaria antigens suitable for use in large-scale epidemiological studies. Results obtained using sera from 567 persons from the Gambia indicated that the micro-ELISA method using parasitized red blood cell extract did not reliably quantitate antimalarial antibodies, especially in young children. In contrast, two micro-ELISA methods that employed purified, defined antigens (a polypeptide of M_r = 41 000 present in rhoptries, and a 31-1 fusion polypeptide corresponding to a merozoite surface antigen) permitted the precise determination of antimalarial antibodies in both adults and children. Problems and advantages associated with the use of the M_r = 41 000 and 31-1 antigens for the determination of antimalarial antibodies are discussed. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 889 890 891 892 893 894 895 896