文章基本信息

标题：Evidence implicating MHC genes in the immunological nonresponsiveness to the Plasmodium falciparum CS protein.
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作者：M. F. Good ; S. Kumar ; A. S. De Groot 等
期刊名称：Bulletin of the World Health Organization
印刷版ISSN：0042-9686
出版年度：1990
卷号：68
期号：Suppl
页码：80-84
语种：English
出版社：World Health Organisation
摘要：The circumsporozoite (CS) protein is a major candidate vaccine antigen for the sporozoite stage of malaria. Both cytotoxic T cells (CTL) and antibody specific for the CS protein are thought to be important in protection. By examining the immune response in mice and humans we have shown that genes mapping to the major histocompatibility complex (MHC) are important for immune responsiveness. F1 mice between high antibody responders and low antibody responders are high antibody responders, suggesting that in this model immune suppressor genes do not control the immune response. Using synthetic peptides to map epitopes for CTL and helper T cells (which are important for the antibody response) we have shown that the T-cell epitopes are located in the polymorphic region of the protein, and we hypothesize that T cells have indeed selected the variation observed in the CS protein. The success of subunit vaccines will depend on the pattern of variation in different geographical locations, the ability to construct multivalent vaccines containing different variant epitopes from this protein, and on the existence of other sporozoite and liver-stage proteins involved in protection. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (727K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 80 81 82 83 84