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标题：Testing of Plasmodium vivax CS proteins in Saimiri monkeys.
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作者：W. E. Collins
期刊名称：Bulletin of the World Health Organization
印刷版ISSN：0042-9686
出版年度：1990
卷号：68
期号：Suppl
页码：42-46
语种：English
出版社：World Health Organisation
摘要：Recombinant proteins directed against the circumsporozoite (CS) protein of Plasmodium vivax were tested for safety, immunogenicity, and efficacy in Saimiri sciureus boliviensis monkeys. The monkeys were immunized 3 times with either alum or muramyl tripeptide as adjuvant, and were challenged with 10,000 sporozoites (P. vivax, Salvador I strain) from mosquitos infected by membrane feeding on gametocytes from chimpanzees. Antibodies, measured by indirect immunofluorescent antibody tests and enzyme-linked immunosorbent assays, were induced by all the vaccines. Six of 42 monkeys immunized with recombinant or synthetically produced vaccines were protected. Two of 6 monkeys immunized with irradiated sporozoites were protected. Saimiri appear to be less susceptible than are humans to sporozoite infection. Therefore, the predictive usefulness of this model must await the results of comparable trials in monkeys and humans. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (631K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 42 43 44 45 46