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标题：Human immunization with attenuated sporozoites.
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作者：K. H. Rieckmann
期刊名称：Bulletin of the World Health Organization
印刷版ISSN：0042-9686
出版年度：1990
卷号：68
期号：Suppl
页码：13-16
语种：English
出版社：World Health Organisation
摘要：Studies conducted between 1971 and 1975 showed that attenuated sporozoites can induce protection against human malaria. Three volunteers were protected against challenge with either a homologous or heterologous strain of Plasmodium falciparum after being exposed to a total of 440-987 X-irradiated mosquitos on 6-8 occasions over a period of 10-38 weeks. Protection lasted for at least 8 weeks, but not 16 weeks, after the last immunization with irradiated sporozoites. Another 7 volunteers were not protected against challenge with a homologous strain after exposure to a total of fewer than 200 irradiated mosquitos, infected with either P. falciparum or P. vivax, on 2-4 occasions over a period of 4-17 weeks. These studies provide an encouraging basis for pursuing the development of a sporozoite vaccine against human malaria. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (323K), or click on a page image below to browse page by page. 13 14 15 16