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标题：Falciparum malaria in eastern Thailand: a randomized trial of the efficacy of a single dose of mefloquine.
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作者：A. L. Fontanet ; B. D. Johnston ; A. M. Walker 等
期刊名称：Bulletin of the World Health Organization
印刷版ISSN：0042-9686
出版年度：1994
卷号：72
期号：1
页码：73-78
语种：English
出版社：World Health Organisation
摘要：Reported are the results of a randomized trial of a single dose of mefloquine (15 mg/kg or 25 mg/kg body weight) for the treatment of uncomplicated multidrug-resistant falciparum malaria. Of the 110 adult patients enrolled in the study 57 were randomly assigned to the 15 mg/kg group and 53 to the 25 mg/kg group. The baseline characteristics of the patients did not differ significantly in the two groups, except that those in the 15 mg/kg group had lower haemoglobin levels. Adverse effects following treatment were commoner in the 25 mg/kg group, but not significantly so. Seven patients (6%) did not complete the 42-day follow-up. The parasitological failure rates in the 15 and 25 mg/kg groups were, respectively, 50% (28/56) and 43% (25/53) on day 28, and 62% (33/53) and 56% (28/50) on day 42. Treatment failures were not correlated with the serum mefloquine concentrations on day 2, and 13 out of 19 patients with serum mefloquine concentrations > 2000 micrograms/l on day 2 showed an R response during the follow-up. The mean ratio between the concentrations of the (SR)-(-) and (RS)-(+) enantiomers of mefloquine on day 2 was 3.37, indicating that there are differences in their pharmacokinetics. Re-treatment of patients who showed an R response with seven days of quinine (30 mg.kg-1.day-1)+tetracycline (25 mg.kg-1.day-1) was successful in 93% of the cases. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (847K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 73 74 75 76 77 78