文章基本信息

标题：Systematic review and meta-analysis of imipenem-resistant Pseudomonas aeruginosa prevalence in Iran
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作者：Hamid Vaez ; Amin Salehi-Abargouei ; Farzad Khademi 等
期刊名称：Germs
印刷版ISSN：2248-2997
出版年度：2017
卷号：7
期号：2
页码：86
出版社：European HIV/AIDS and Infectious Diseases Academy
摘要：Introduction Imipenem-resistant Pseudomonas aeruginosa (IRPA), due to resistance to different classes of antibiotics and its remarkable capacity to survive in harsh and adverse conditions such as those in the hospital environment, is considered a serious threat to the healthcare system. Given the great impact of IRPA on patients’ outcome and in order to possibly improve antibiotic prescription, this study was conducted to determine the prevalence of clinical isolates of IRPA in different parts of Iran.Methods A systematic literature search was performed in PubMed, Web of Science, Google Scholar and Scopus, as well as in two Iranian domestic search engines, i.e., Iranian Scientific Information Database and Magiran. Finally, after applying exclusion and inclusion criteria 37 articles with full-texts describing the prevalence of imipenem-resistant P. aeruginosa were selected for meta-analysis and systematic review.Results The pooled estimation of 5227 P. aeruginosa isolates in this analysis showed that the percentage of imipenem-resistant P. aeruginosa is about 54% in the Iranian population (95%CI: 0.47-0.62, logit event rate=0.19, 95%CI: -0.12,0.49).Conclusion The findings of this analysis show that in the majority of Iranian hospitals the relative frequency of IRPA is high, therefore, in order to prevent further dissemination of IRPA, more appropriate antibiotic prescription and infection control policies must be implemented by decision-makers.
关键词：Imipenem-resistant Pseudomonas aeruginosa; carbapenem resistance; Pseudomonas aeruginosa; multidrug resistant Pseudomonas aeruginosa