文章基本信息

标题：Characterization of Inclusion Complexes between Miconazole and Different Cyclodextrin Derivatives
本地全文：下载
作者：Hajnal Kelemen ; Gabriel Hancu ; Serban Andrei Gâz-Florea 等
期刊名称：Acta Medica Marisiensis
电子版ISSN：2247-6113
出版年度：2018
卷号：64
期号：2
页码：70-76
DOI：10.2478/amma-2018-0012
语种：English
出版社：Walter de Gruyter GmbH
摘要：Objective : Miconazole, an imidazole antifungal derivative, is a very hydrophobic compound, a major drawback in obtaining topical pharmaceutical formulations with optimal bioavailability. Cyclodextrins (CDs) may increase local drug delivery by enhancing the drug release and/or permeation. The aim of the study is the characterization of inclusion complexes between miconazole and different CD derivatives. Methods : Several CD derivatives were tested in the experiments. The binary systems between miconazole and different CDs were prepared in 1:1 molar ratios by physical-mixture and kneading methods. Differential scanning calorimetry (DSC) and Fourier transformed-infrared spectroscopy (FT-IR) methods were used to characterize solid state interactions between miconazole and CDs in their binary systems. Results : The FT-IR analysis suggests the formation of a new solid phase, indicating a molecular interaction between the components. The DSC analysis sustains the hypothesis of formation of partial inclusion complexes between miconazole nitrate and CD. Conclusion : The thermic behaviour of the complexes depends both on the preparation method and the composition of the products.
关键词：miconazole ; cyclodextrins ; complexation ; differential scanning calorimetry ; Fourier transform-infrared spectroscopy