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标题：Effect of 2.45 GHz Pulsed Microwave Radiation on Hippocampus Mediated Behaviour: in a Specific Relation to the Expression of Rac1, Cdc42 and pCREB
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作者：Manoj Kumar ; Surya Pal Singh ; Chandra Mohini Chaturvedi 等
期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2017
卷号：6
期号：10
页码：20718
DOI：10.15680/IJIRSET.2017.0610163
出版社：S&S Publications
摘要：Present study was aimed to investigate the effect of pulsed microwave exposure on anxiety & depressionlike behaviour and spatial memory function of laboratory mouse. Mice were exposed to 2.45 GHz frequency with 16and 217 Hzpulse modulation at the rate of 1 msec, pulse width 500 μsec& 50 % duty cycle; specific absorption rate(SAR) of 0.017 W/Kg for 30 days (2 hrs daily, 10.00 to 12.00 IST ). Mice behaviour was monitored in differentbehavioural paradigms and hippocampal tissue was processed for expression analysis of Rac1, Cdc 42 and pCREB(S-133).Our results denote that 16 and 217 Hz did not induce anxiety and depression like behaviour analysed in OFT andFST respectively. Spatial memory function was remained unaffected following pulsed 16 and 217 MW exposures(except decline in time spent in target quadrant of 217 Hz). Expression levels of the above proteins complied with thebehavioural findings and remain unaltered following 16 and 217 MW exposure. Findings of the present studysuggested that 2.45 GHz with the 16 and 217 Hz modulation is unable to trigger any adverse effect on behaviouralfunction of laboratory mouse.
关键词：microwave; spatial memory; Hz; anxiety and depression like behaviour