文章基本信息

标题：Preclinical Toxicity Studies of RISUGadv as A New Molecule for the Prevention and Management of Prostate Cancer
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作者：Rama Kant Singh ; Falgun Wanganuji Bansode ; Sharad Sharma 等
期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2017
卷号：6
期号：7
页码：12845
DOI：10.15680/IJIRSET.2017.0607053
出版社：S&S Publications
摘要：The aim of this study was to assess the toxic effect of the newly developed contraceptive RISUGadv inmale Charles Foster rats. Young and healthy male rats of Charles Foster strain were employed in the study. They wererandomly assigned to two groups, control and treated, each consisting of fifteen animals. The contraceptive DMSO andRISUGadv was injected surgically in the vas deferens of the anesthetized control and treated group rats, respectivelyand observed for a period of 14 days. Initial and final body weights and food/water consumption of the animals wererecorded. The haematological and biochemical parameters were analyzed. At the end of the study all the animals weresacrificed and necropsied, the organ weight was taken and their histopathological slides were prepared for microscopicexamination. Results on body weight, food and water consumption, haematology, biochemistry, absolute and relativeorgan weights did not show any significant change and were well within the limit of normalcy. General health checkup,mortality, gross and microscopic examination of organs and tissues also did not reveal any sign of toxicity. Fromthe toxicity point of view this newly developed injectable contraceptive RISUGadv does not have any adverse effectand is safe to use.
关键词：RISUGadv; Male contraceptive agent; Toxicity profile.