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标题：Issues in the risk assessment of chromium.
本地全文：下载
作者：R E Albert
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：1991
卷号：92
页码：91
语种：English
出版社：OCR Subscription Services Inc
摘要：Although hexavalent chromium is well established as a human carcinogen by the inhalation route, there are significant uncertainties in the quantitative estimation of cancer risk. One of the important uncertainties is the assumption that the carcinogenic potency, determined under conditions of occupational exposure where most workers were cigarette smokers, applies to the nonsmoking individual in the general population. There is substantial evidence that carcinogenicity is a function of the rate of cell turnover in the target tissue. The chromate worker would be expected to have a relatively high rate of cell proliferation in the bronchial mucosa due to airborne irritants and smoking. The potency of chromium might therefore be relatively high under conditions of occupational exposure. This problem in quantitative risk assessment applies equally well to another important indoor pollutant, radon. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (421K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 91 92