摘要：New approaches to the risk assessment process are needed that might be more definitive and satisfying to the scientific community, interest groups, and the public at large. This commentary examines an alternative approach that is based on understanding the relationships of chemical structure and reactivity properties to the toxicokinetic behavior of chemicals in biological systems. This approach is based on the likelihood that there is a limited number of triggering (reactivity) mechanisms by which chemicals can express their toxicity at the molecular level. The fundamental importance of electrophilic character of chemicals as a determinant of their critical molecular reactivities and interactions with biological material in the expression of toxicity is supported. Such an approach also takes advantage of the maturing field of theoretical/computational chemistry in understanding important molecular recognition and reactivity processes (both qualitatively and quantitatively) for chemicals that can underlie their biological/toxicological activity. A process that permits assessment of reaction equivalents delivered to biological systems may hold promise for grouping chemicals by common triggering mechanisms with clearly delineated toxicological endpoints. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.9M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 810 811 812 813 814 815 816
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