文章基本信息

标题：Semen Quality in Relation to Xenohormone and Dioxin-like Serum Activity Among Inuits and Three European Populations
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作者：Gunnar Toft ; Manhai Long ; Tanja Krüger 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2007
卷号：115
期号：Suppl 1
页码：15-20
DOI：10.1289/ehp.9352
语种：English
出版社：OCR Subscription Services Inc
摘要：Background Semen quality in humans may be influenced by exposure to endocrine-disrupting compounds. Objectives We analyzed associations between semen characteristics and serum xenoestrogen receptor (XER), xenoandrogen receptor (XAR), and aryl hydrocarbon receptor (AhR) transactivity. XER and XAR activity were measured in serum samples cleared for endogenous steroid hormones and AhR activity in raw lipophilic serum extracts free of proteins. Results All together, 319 men from Warsaw (Poland), Greenland, Kharkiv (Ukraine), and Sweden provided semen and blood samples. No strong and consistent associations between xenobiotic activity and semen quality measures were observed in the four populations. However, when the data were combined across populations sperm concentration increased 40% per unit increase in XER activity [95% confidence interval (CI), 1–79%] in the subgroup with XER activity below the reference level. Among subjects with XER activity above the reference level an increase of 14% (95% CI, 2–28%) was found. Furthermore, an increase of 10% motile sperm per unit increase in XER activity below reference level (95% CI, 0.2–20) was found. We are unable to exclude that the associations are chance findings. Conclusion Alteration of XER, XAR, or AhR transactivity within the range found in serum from the general European and Inuit population seems not to markedly deteriorate sperm cell concentration, motility, or morphology in adult men.
关键词：androgen receptor; aryl hydrocarbon receptor; CALUX; endocrine disruption; estrogen receptor; human; sperm