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标题：Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study
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作者：Cyntia B. Manzano-Salgado ; Maribel Casas ; Maria-Jose Lopez-Espinosa 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2017
卷号：125
期号：9
页码：097018
DOI：10.1289/EHP1330
语种：English
出版社：OCR Subscription Services Inc
摘要：Background: Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, but evidence is scarce and inconsistent. Objectives: We estimated associations between prenatal PFAS exposures and outcomes relevant to cardiometabolic risk, including a composite CM-risk score. Methods: We measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in maternal plasma (first trimester). We assessed weight gain from birth until 6 mo. At 4 and 7 y, we calculated the age- and sex-specific z -scores for BMI, waist circumference (WC), and blood pressure (BP) ( n ≈ 1,000 ). At age 4, we calculated the age-, sex-, and region-specific z -scores for cholesterol, triglycerides (TGs), high-density (HDL-C), and low-density lipoprotein cholesterol (LDL-C) ( n = 627). At age 4, we calculated a CM-risk score ( n = 386) as the sum of the individual age-, sex-, and region-specific z -scores for WC, BP, HDL-C, and TGs. We used the average between the negative of HDL-C z -score and TGs z -score to give similar weight to lipids and the other components in the score. A higher score indicates a higher cardiometabolic risk at age 4. Results: PFOS and PFOA were the most abundant PFAS (geometric mean: 5.80 and 2.32 ng/mL, respectively). In general, prenatal PFAS concentrations were not associated with individual outcomes or the combined CM-risk score. Exceptions were positive associations between prenatal PFHxS and TGs z -score [for a doubling of exposure, β = 0.11; 95% confidence interval (CI): 0.01, 0.21], and between PFNA and the CM-risk score (β = 0.60; 95% CI: 0.04, 1.16). There was not clear or consistent evidence of modification by sex. Conclusions: We observed little or no evidence of associations between low prenatal PFAS exposures and outcomes related to cardiometabolic risk in a cohort of Spanish children followed from birth until 7 y. https://doi.org/10.1289/EHP1330