文章基本信息

标题：Influence of Tetrabromobisphenol A, with or without Concurrent Triclosan, upon Bisphenol A and Estradiol Concentrations in Mice
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作者：Tyler Pollock ; Leanna Mantella ; Vanessa Reali 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2017
卷号：125
期号：8
页码：087014
DOI：10.1289/EHP1329
语种：English
出版社：OCR Subscription Services Inc
摘要：Background: Humans are commonly exposed to multiple environmental chemicals, including tetrabromobisphenol A (TBBPA; a flame retardant), triclosan (an antimicrobial agent), and bisphenol A (BPA; polycarbonate plastics). These chemicals are readily absorbed and may interact with each other. Objectives: We sought to determine whether TBBPA, given alone or in combination with triclosan, can modulate the concentrations of BPA and 17β - estradiol (E2). Methods: Female and male CF-1 mice were each given a subcutaneous injection of 0–27 mg TBBPA, with or without concurrent 0.33 mg triclosan, followed by dietary administration of 50 μg/kg body weight ¹⁴C - BPA. Radioactivity was measured in blood serum and tissues through liquid scintillation counting. In subsequent experiments, female and male CF-1 mice were each given a subcutaneous injection of 0 or 1 mg TBBPA and E2 was measured in urine 2–12 h after injection. Results: Doses as low as 1 mg TBBPA significantly elevated ¹⁴C - BPA concentrations in the uterus and ovaries of females; in the testes, epididymides, vesicular-coagulating glands, and preputial glands of males; and in blood serum, heart, lungs, and kidneys of both sexes; urinary E2 concentrations were also elevated. Lower doses of TBBPA or triclosan that had no effects on their own elevated ¹⁴C - BPA concentrations when the two substances were given concurrently. Conclusion: These data indicate that TBBPA, triclosan, and BPA interact in vivo , consistent with evidence that TBBPA and triclosan inhibit enzymes that are critical for BPA and E2 metabolism. https://doi.org/10.1289/EHP1329