文章基本信息

标题：Ambient Air Pollution and Cancer Mortality in the Cancer Prevention Study II
本地全文：下载
作者：Michelle C. Turner ; Daniel Krewski ; W. Ryan Diver 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2017
卷号：125
期号：8
页码：087013
DOI：10.1289/EHP1249
语种：English
出版社：OCR Subscription Services Inc
摘要：Background: The International Agency for Research on Cancer classified both outdoor air pollution and airborne particulate matter as carcinogenic to humans (Group 1) for lung cancer. There may be associations with cancer at other sites; however, the epidemiological evidence is limited. Objective: The aim of this study was to clarify whether ambient air pollution is associated with specific types of cancer other than lung cancer by examining associations of ambient air pollution with nonlung cancer death in the Cancer Prevention Study II (CPS-II). Methods: Analysis included 623,048 CPS-II participants who were followed for 22 y (1982–2004). Modeled estimates of particulate matter with aerodynamic diameter < 2.5 µm (PM_2.5) (1999–2004), nitrogen dioxide (NO₂) (2006), and ozone (O₃) (2002–2004) concentrations were linked to the participant residence at enrollment. Cox proportional hazards models were used to estimate associations per each fifth percentile–mean increment with cancer mortality at 29 anatomic sites, adjusted for individual and ecological covariates. Results: We observed 43,320 nonlung cancer deaths. PM_2.5 was significantly positively associated with death from cancers of the kidney {adjusted hazard ratio (HR) per 4.4 μg/m³ = 1.14 [95% confidence interval (CI): 1.03, 1.27]} and bladder [HR = 1.13 (95% CI: 1.03, 1.23)]. NO₂ was positively associated with colorectal cancer mortality [HR per 6.5 ppb = 1.06 (95% CI: 1.02, 1.10). The results were similar in two-pollutant models including PM_2.5 and NO₂ and in three-pollutant models with O₃. We observed no statistically significant positive associations with death from other types of cancer based on results from adjusted models. Conclusions: The results from this large prospective study suggest that ambient air pollution was not associated with death from most nonlung cancers, but associations with kidney, bladder, and colorectal cancer death warrant further investigation. https://doi.org/10.1289/EHP1249