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标题：Estimating Acute Cardiovascular Effects of Ambient [... formula ...] Metals
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作者：Dongni Ye ; Mitchel Klein ; James A. Mulholland 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2018
卷号：126
期号：2
页码：027007
DOI：10.1289/EHP2182
语种：English
出版社：OCR Subscription Services Inc
摘要：Background: Few epidemiologic studies have investigated health effects of water-soluble fractions of PM_2.5 metals, the more biologically accessible fractions of metals, in their attempt to identify health-relevant components of ambient PM_2.5. Objectives: In this study, we estimated acute cardiovascular effects of PM_2.5 components in an urban population, including a suite of water-soluble metals that are not routinely measured at the ambient level. Methods: Ambient concentrations of criteria gases, PM_2.5, and PM_2.5 components were measured at a central monitor in Atlanta, Georgia, during 1998–2013, with some PM_2.5 components only measured during 2008–2013. In a time-series framework using Poisson regression, we estimated associations between these pollutants and daily counts of emergency department (ED) visits for cardiovascular diseases in the five-county Atlanta area. Results: Among the PM_2.5 components we examined during 1998–2013, water-soluble iron had the strongest estimated effect on cardiovascular outcomes [ R R ^ = 1.012 (95% CI: 1.005, 1.019), per interquartile range increase (20.46 ng/m³)]. The associations for PM_2.5 and other PM_2.5 components were consistent with the null when controlling for water-soluble iron. Among PM_2.5 components that were only measured during 2008–2013, water-soluble vanadium was associated with cardiovascular ED visits [ R R ^ = 1.012 (95% CI: 1.000, 1.025), per interquartile range increase (0.19 ng/m³)]. Conclusions: Our study suggests cardiovascular effects of certain water-soluble metals, particularly water-soluble iron. The observed associations with water-soluble iron may also point to certain aspects of traffic pollution, when processed by acidifying sulfate, as a mixture harmful for cardiovascular health. https://doi.org/10.1289/EHP2182