文章基本信息

标题：Ambient Air Pollution and Chronic Bronchitis in a Cohort of U.S. Women
本地全文：下载
作者：Laura G. Hooper ; Michael T. Young ; Joshua P. Keller 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2018
卷号：126
期号：2
页码：027005
DOI：10.1289/EHP2199
语种：English
出版社：OCR Subscription Services Inc
摘要：Background: Limited evidence links air pollution exposure to chronic cough and sputum production. Few reports have investigated the association between long-term exposure to air pollution and classically defined chronic bronchitis. Objectives: Our objective was to estimate the association between long-term exposure to particulate matter (diameter < 10 μm, PM₁₀; < 2.5 μm, PM_2.5), nitrogen dioxide (NO₂), and both incident and prevalent chronic bronchitis. Methods: We estimated annual average PM_2.5, PM₁₀, and NO₂ concentrations using a national land-use regression model with spatial smoothing at home addresses of participants in a prospective nationwide U.S. cohort study of sisters of women with breast cancer. Incident chronic bronchitis and prevalent chronic bronchitis, cough and phlegm, were assessed by questionnaires. Results: Among 47,357 individuals with complete data, 1,383 had prevalent chronic bronchitis at baseline, and 647 incident cases occurred over 5.7-y average follow-up. No associations with incident chronic bronchitis were observed. Prevalent chronic bronchitis was associated with PM₁₀ [adjusted odds ratio (aOR) per interquartile range (IQR) difference (5.8 μg/m³) = 1.07; 95% confidence interval (CI): 1.01, 1.13]. In never-smokers, PM_2.5 was associated with prevalent chronic bronchitis (aOR = 1.18 per IQR difference; 95% CI: 1.04, 1.34), and NO₂ was associated with prevalent chronic bronchitis (aOR = 1.10; 95% CI = 1.01, 1.20), cough (aOR = 1.10; 95% CI: 1.05, 1.16), and phlegm (aOR = 1.07; 95% CI: 1.01, 1.14); interaction p -values (nonsmokers vs. smokers) < 0.05. Conclusions: PM₁₀ exposure was related to chronic bronchitis prevalence. Among never-smokers, PM_2.5 and NO₂ exposure was associated with chronic bronchitis and component symptoms. Results may have policy ramifications for PM₁₀ regulation by providing evidence for respiratory health effects related to long-term PM₁₀ exposure. https://doi.org/10.1289/EHP2199