文章基本信息

标题：Vitamin D3 Concentration Correlates with the Severity of Multiple Sclerosis
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作者：Saeed Shahbeigi ; Hossein Pakdaman ; Seyed-Mohammad Fereshtehnejad 等
期刊名称：INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
印刷版ISSN：2008-7802
出版年度：2013
卷号：4
期号：5
页码：585-591
语种：English
出版社：ISFAHAN UNIVERSITY OF MEDICAL SCIENCES
摘要：Background: To investigate the possible association between serum 25(OH) vitamin D₃ concentration and the severity of disease in Iranian patients with multiple sclerosis (MS) and to compare this concentration with a matched control group. Methods: This was an analytical cross-sectional study performed at Jondishapour Neurology Clinic in Tehran, Iran. Patients with relapsing–remitting MS were categorized by disease severity: mild [0≤ Expanded Disability Status Scale (EDSS) ≤3], moderate (3.5≤EDSS≤5.5), and severe (6≤EDSS). Serum concentrations of 25(OH) vitamin D₃, calcium, phosphorus, magnesium, and parathyroid hormone were measured in 98 MS patients and 17 healthy age- and sex-matched controls. Fisher's exact, Kruskal–Wallis, Mann–Whitney U test, and independent t and Spearman rank correlation tests were used. Results: Serum 25(OH) vitamin D₃ concentration was significantly lower in patients with MS, especially in the severe MS subgroup, compared with healthy controls ( P =0.047). There was a statistically significant inverse correlation between 25(OH) vitamin D₃ concentration and EDSS score ( P =0.049, R =−0.168 by Spearman rank correlation test), which was observed in women only ( P =0.044, R =−0.199). Conclusions: Our findings not only further disclose the lower level of vitamin D in MS patients in comparison with healthy controls, but also support the association between vitamin D and disease severity in MS.
关键词：25(OH) vitamin D 3 ; disease severity; multiple sclerosis