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标题：Human Herpesvirus-6 and Epstein–Barr Virus Infections at Different Histopathological Grades of Oral Squamous Cell Carcinomas
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作者：Shirin Saravani ; Ebrahim Miri-Moghaddam ; Nima Sanadgol 等
期刊名称：INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
印刷版ISSN：2008-7802
出版年度：2014
卷号：5
期号：10
页码：1231-1238
语种：English
出版社：ISFAHAN UNIVERSITY OF MEDICAL SCIENCES
摘要：Background: The aim of this study was to determine the prevalence and viral load of Epstein–Barr virus (EBV) and Human herpesvirus-6 (HHV-6) in different histopathologic grades of oral squamous cell carcinoma (OSCC). Methods: Forty-five formalin-fixed paraffin-embedded tissue section of OSCC patients were analyzed by quantitative real-time polymerase chain reaction for detection of EBV and HHV-6. Results: The mean age of the patients was 58.6 years, 69% of whom were female, and 31% were male. Overall, the positive rate for EBV and HHV-6 were 16.7% and 27.1%, respectively; and the mean viral load EBV was 27.9 × 10³ and 38.5 × 10³ for HHV-6. No correlation was demonstrated between the viral load of EBV DNA ( P = 0.35) and HHV-6 ( P = 0.38) at the different OSCC histopathologic grades. Conclusions: These findings neither lend support to the hypothesis that EBV and HHV-6 are directly involved in OSCC nor rule out the possibility that these viruses play an indirect role in carcinogenesis in this area.
关键词：Epstein–Barr virus; herpesvirus-6; infection; oral cancer