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  • 标题:Human Herpesvirus-6 and Epstein–Barr Virus Infections at Different Histopathological Grades of Oral Squamous Cell Carcinomas
  • 本地全文:下载
  • 作者:Shirin Saravani ; Ebrahim Miri-Moghaddam ; Nima Sanadgol
  • 期刊名称:INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
  • 印刷版ISSN:2008-7802
  • 出版年度:2014
  • 卷号:5
  • 期号:10
  • 页码:1231-1238
  • 语种:English
  • 出版社:ISFAHAN UNIVERSITY OF MEDICAL SCIENCES
  • 摘要:Background: The aim of this study was to determine the prevalence and viral load of Epstein–Barr virus (EBV) and Human herpesvirus-6 (HHV-6) in different histopathologic grades of oral squamous cell carcinoma (OSCC). Methods: Forty-five formalin-fixed paraffin-embedded tissue section of OSCC patients were analyzed by quantitative real-time polymerase chain reaction for detection of EBV and HHV-6. Results: The mean age of the patients was 58.6 years, 69% of whom were female, and 31% were male. Overall, the positive rate for EBV and HHV-6 were 16.7% and 27.1%, respectively; and the mean viral load EBV was 27.9 × 103 and 38.5 × 103 for HHV-6. No correlation was demonstrated between the viral load of EBV DNA ( P = 0.35) and HHV-6 ( P = 0.38) at the different OSCC histopathologic grades. Conclusions: These findings neither lend support to the hypothesis that EBV and HHV-6 are directly involved in OSCC nor rule out the possibility that these viruses play an indirect role in carcinogenesis in this area.
  • 关键词:Epstein–Barr virus; herpesvirus-6; infection; oral cancer
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