文章基本信息

标题：Biological effects of radiation on cancer cells
本地全文：下载
作者：Jin-song Wang ; Hai-juan Wang ; Hai-li Qian 等
期刊名称：Military Medical Research
印刷版ISSN：2054-9369
出版年度：2018
卷号：5
期号：1
页码：20
DOI：10.1186/s40779-018-0167-4
语种：English
出版社：BioMed Central
摘要：With the development of radiotherapeutic oncology, computer technology and medical imaging technology, radiation therapy has made great progress. Research on the impact and the specific mechanism of radiation on tumors has become a central topic in cancer therapy. According to the traditional view, radiation can directly affect the structure of the DNA double helix, which in turn activates DNA damage sensors to induce apoptosis, necrosis, and aging or affects normal mitosis events and ultimately rewires various biological characteristics of neoplasm cells. In addition, irradiation damages subcellular structures, such as the cytoplasmic membrane, endoplasmic reticulum, ribosome, mitochondria, and lysosome of cancer cells to regulate various biological activities of tumor cells. Recent studies have shown that radiation can also change the tumor cell phenotype, immunogenicity and microenvironment, thereby globally altering the biological behavior of cancer cells. In this review, we focus on the effects of therapeutic radiation on the biological features of tumor cells to provide a theoretical basis for combinational therapy and inaugurate a new era in oncology.
关键词：Radiation ; Cancer cells ; Biological features ; Combinational therapy