文章基本信息

标题：LA-iMageS: a software for elemental distribution bioimaging using LA–ICP–MS data
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作者：Hugo López-Fernández ; Gustavo de S. Pessôa ; Marco A. Z. Arruda 等
期刊名称：Journal of Cheminformatics
印刷版ISSN：1758-2946
电子版ISSN：1758-2946
出版年度：2016
卷号：8
期号：1
页码：65
DOI：10.1186/s13321-016-0178-7
语种：English
出版社：BioMed Central
摘要：The spatial distribution of chemical elements in different types of samples is an important field in several research areas such as biology, paleontology or biomedicine, among others. Elemental distribution imaging by laser ablation inductively coupled plasma mass spectrometry (LA–ICP–MS) is an effective technique for qualitative and quantitative imaging due to its high spatial resolution and sensitivity. By applying this technique, vast amounts of raw data are generated to obtain high-quality images, essentially making the use of specific LA–ICP–MS imaging software that can process such data absolutely mandatory. Since existing solutions are usually commercial or hard-to-use for average users, this work introduces LA-iMageS, an open-source, free-to-use multiplatform application for fast and automatic generation of high-quality elemental distribution bioimages from LA–ICP–MS data in the PerkinElmer Elan XL format, whose results can be directly exported to external applications for further analysis. A key strength of LA-iMageS is its substantial added value for users, with particular regard to the customization of the elemental distribution bioimages, which allows, among other features, the ability to change color maps, increase image resolution or toggle between 2D and 3D visualizations.
关键词：Elemental distribution ; Laser ablation ; LA–ICP–MS imaging ; Software