文章基本信息

标题：A comprehensive assessment of urinary iodine concentration and thyroid hormones in New Zealand schoolchildren: a cross-sectional study
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作者：Sheila A Skeaff ; Christine D Thomson ; Noela Wilson 等
期刊名称：Nutrition Journal
印刷版ISSN：1475-2891
电子版ISSN：1475-2891
出版年度：2012
卷号：11
期号：1
页码：31
DOI：10.1186/1475-2891-11-31
语种：English
出版社：BioMed Central
摘要：Insufficient iodine in children’s diets is of concern because thyroid hormones are needed for normal growth and development, particularly of the brain. This study aimed to carry out a comprehensive assessment of the iodine status of New Zealand schoolchildren using a range of biochemical indices suitable for populations (i.e. urinary iodine concentration) and individuals (i.e. thyroid hormones). The New Zealand National Children’s Nutrition Survey was a cross‒sectional survey of a representative sample of schoolchildren aged 5‒14 years. Children were asked to provide a casual urine sample for the determination of urinary iodine concentration (UIC) and a blood sample for the determination of thyroglobulin (Tg), Thyroid Stimulating Hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3). The median UIC was 68 μg/L (n = 1153), which falls between 50‒99 μg/L indicative of mild iodine deficiency. Furthermore, 29% of children had an UIC 100 μg/L (P = 0.001). The mean TSH (1.7 mU/L), fT4 (14.9 pmol/L), and fT3 (6.0 pmol/L) concentrations for these mildly iodine deficient New Zealand children fell within normal reference ranges. The UIC and Tg concentration indicate that New Zealand schoolchildren were mildly iodine deficient according to WHO/UNICEF/ICCIDD, and both are suitable indices to assess iodine status in populations or groups. The normal concentrations of TSH, fT4 and fT3 of these children suggest that these thyroid hormones are not useful indices of mild iodine deficiency.
关键词：Iodine ; Iodine deficiency ; Urinary iodine concentration ; Children ; Thyroid hormones