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  • 标题:Beta-Blockers and Depression in Elderly Hypertension Patients in Primary Care
  • 作者:Lianne Ringoir, PhD ; Susanne S. Pedersen, PhD ; Jos W.M.G. Widdershoven, MD, PhD
  • 期刊名称:Family Medicine
  • 印刷版ISSN:0742-3225
  • 电子版ISSN:1938-3800
  • 出版年度:2014
  • 卷号:46
  • 期号:6
  • 页码:447-53
  • 出版社:Society of Teachers of Family Medicine
  • 摘要:Background and Objectives: Previous findings regarding a possible association between beta-blocker use and depression are mixed. To our knowledge there have been no studies investigating the association of beta-blockers with depression in primary care hypertension patients without previous myocardial infarction. The aim of this study was to determine the relation between lipophilic beta-blocker use and depression in elderly primary care patients with hypertension. Methods: This was a cross-sectional study in primary care practices located in the South of The Netherlands. Primary care hypertension patients without previous myocardial infarction or heart failure (n=573), aged between 60 and 85 years (mean age=70±6.6), were included. All patients underwent a structured interview that included a self-report questionnaire to assess depression (PHQ-9), which was divided in four groups (PHQ-9 score of 0, 1–3, 4–8, 9 or higher). Results: A PHQ-9 score of 0 was more prevalent in non-beta-blocker users versus lipophilic beta-blocker users (46% versus 35%), a PHQ-9 score of 4–8 was less prevalent in non-beta-blocker users as compared with lipophilic beta-blocker users (14% versus 25%). A chi-squared test showed that lipophilic beta-blocker users as compared to non-beta-blockers users were more likely to be in a higher depression category. Ordinal regression showed a significant relationship between use of lipophilic beta-blockers and depression (OR=1.60, 95% CI=1.08–2.36) when adjusting for potential confounders. Conclusions: Our findings show that primary care hypertension patients who use a lipophilic beta-blocker are more likely to have higher depression scores than those who do not use a lipophilic beta-blocker.
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