文章基本信息

标题：Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives
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作者：Hiroyuki Kobayashi ; Takashi Misawa ; Makoto Oba 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2018
卷号：66
期号：5
页码：575-580
DOI：10.1248/cpb.c18-00079
语种：English
出版社：The Pharmaceutical Society of Japan
摘要：We designed and synthesized a series of cell-penetrating peptides containing cationic proline derivatives (Pro^Gu) that exhibited responsive changes in their secondary structures to the cellular environment. Effects of the peptide length and steric arrangement of the side chain in cationic proline derivatives [Pro^4SGu and Pro^4RGu] on their secondary structures and cell membrane permeability were investigated. Moreover, peptides 3 and 8 exhibited efficient intracellular delivery of plasmid DNA.
关键词：cell-penetrating peptide;cationic proline derivative;cellular environment;drug delivery system (DDS) carrier