文章基本信息

标题：Semi-synthesis of Twelve Known 20Z/E Pseudo-Ginsenosides and Their Comparative Study of Antioxidative Activity in Free Radical Induced Hemolysis of Rabbit Erythrocytes
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作者：Manman Li ; Yanping Chen ; Pengfei Zhang 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2018
卷号：66
期号：5
页码：535-540
DOI：10.1248/cpb.c17-00779
语种：English
出版社：The Pharmaceutical Society of Japan
摘要：Twelve pseudo-ginsenosides were synthesized under a mild condition, via a simple three-step called acetylation, elimination-addition and saponification. The inhibitory effects of these twelve pseudo-ginsenosides were screened on the hemolysis of rabbit erythrocytes caused by 2,2′-azobis (2-amidinopropane hydrochloride) (AAPH). It was found that the IC₅₀ values followed the sequence of (20 Z ) pseudo-protopanaxatriol (pseudo-PPT)<(20 Z ) pseudo-protopanaxadiol (pseudo-PPD)<(20 Z ) pseudo-Rh2<(20 E ) pseudo-PPT<(20 E ) pseudo-PPD<(20 E ) pseudo-Rh2<(20 Z ) pseudo-Rg2<(20 E ) pseudo-Rg2
关键词：pseudo ginsenoside;ginsenoside;antioxidant;prooxidant;free radical;hemolysis