文章基本信息

标题：Polycystic Ovary Syndrome and the Role of Metformin in Ovulation Induction
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作者：Fabiana Fraga ; Gabriel Azeredo César Salgado Romeiro ; Larissa Bianca Paiva Cunha de Sá 等
期刊名称：Health
印刷版ISSN：1949-4998
电子版ISSN：1949-5005
出版年度：2018
卷号：10
期号：05
页码：565-576
DOI：10.4236/health.2018.105045
语种：English
出版社：Scientific Research Publishing
摘要：The Polycystic Ovary Syndrome (PCOS) is frequently associated with comorbidities such as obesity, reduced glucose tolerance, hypertension, macrovascular disease and dyslipidemia. The Metabolic syndrome occurs in 30% of women with PCOS. Metformin has increasingly been used in this therapy due to its effects in reducing insulin resistance. Treatment of PCOS aims to reduce the symptoms of hyperandrogenism, regularize the menstrual cycle, reduce metabolic abnormalities, and lower the risk of type 2 diabetes mellitus and of cardiovascular disease. Additionally it is important to prevent hyperplasia and endometrial cancer, and to offer contraception to those who do not wish pregnancy, and to help to induce ovulation to those who do. The effectiveness of metformin in this treatment is assessed in the light of the current best evidence.
关键词：Polycystic Ovary Syndrome;Metformin;Oral Contraceptives;Fertility;Anovulation