A comfortable experimental environment usually enables stress relief among inventors, allowing them to focus on inventing. However, to facilitate smooth and continuous experimental procedures, the public spaces and computing environments of conventional laboratories are usually replete with heavy instruments and interconnected wires; consequently, inventors have limited space to conduct complex experiments. These public spaces and computing environments negatively affect the creative self-efficacy (CSE) of inventors. Based on CSE theory and modified information layout complexity theory, in this study, 100 inventors who had obtained patents were recruited. The results indicated that a wireless cloud public space and computing environment positively moderated and enhanced the relationship between low layout complexity and inventor CSE; conventional public spaces and computing environments featuring cables negatively moderated and weakened the relationship between high layout complexity and inventor CSE. More than 40% of participants highly supported using one electronic tablet to manipulate multiple instruments. The results also revealed that approximately 64% of participants did not think they were essential in promoting critical mass in the laboratory. This finding was significantly different from the degree centrality of creativity perspective. Critical indicators of inventor CSE were found to be inventors’ decision-making capabilities regarding innovative research directions and their communication skills with supervisors.