文章基本信息

标题：Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo
本地全文：下载
作者：Wei Kevin Zhang ; Shan-Shan Tao ; Ting-Ting Li 等
期刊名称：Food & Nutrition Research
印刷版ISSN：1654-661X
出版年度：2016
卷号：60
语种：English
出版社：Co-Action Publishing
摘要：Background: Chronic pain, or sometimes referred to as persistent pain, reduces the life quality of patients who are suffering from chronic diseases such as inflammatory diseases, cancer and diabetes. Hence, herbal medicines draw many attentions and have been shown effective in the treatment or relief of pain. Methods and Results: Here in this study, we used the CFA-injected rats as a sustainable pain model to test the anti-inflammatory and analgesic effect of nutmeg oil, a spice flavor additive to beverages and baked goods produced from the seed of Myristica fragrans tree. Conclusions: We have demonstrated that nutmeg oil could potentially alleviate the CFA-injection induced joint swelling, mechanical allodynia and heat hyperanalgesia of rats through inhibition of COX-2 expression and blood substance P level, which made it possible for nutmeg oil to be a potential chronic pain reliever.
关键词：Nutmeg oil;chronic pain;allodynia;COX-2;substance P