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标题：Insulin Sensitivity and Glucose Homeostasis Can Be Influenced by Metabolic Acid Load
本地全文：下载
作者：Lucio Della Guardia ; Michael Alex Thomas ; Hellas Cena 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2018
卷号：10
期号：5
页码：618
DOI：10.3390/nu10050618
语种：English
出版社：MDPI Publishing
摘要：Recent epidemiological findings suggest that high levels of dietary acid load can affect insulin sensitivity and glucose metabolism. Consumption of high protein diets results in the over-production of metabolic acids which has been associated with the development of chronic metabolic disturbances. Mild metabolic acidosis has been shown to impair peripheral insulin action and several epidemiological findings suggest that metabolic acid load markers are associated with insulin resistance and impaired glycemic control through an interference intracellular insulin signaling pathways and translocation. In addition, higher incidence of diabetes, insulin resistance, or impaired glucose control have been found in subjects with elevated metabolic acid load markers. Hence, lowering dietary acid load may be relevant for improving glucose homeostasis and prevention of type 2 diabetes development on a long-term basis. However, limitations related to patient acid load estimation, nutritional determinants, and metabolic status considerably flaws available findings, and the lack of solid data on the background physiopathology contributes to the questionability of results. Furthermore, evidence from interventional studies is very limited and the trials carried out report no beneficial results following alkali supplementation. Available literature suggests that poor acid load control may contribute to impaired insulin sensitivity and glucose homeostasis, but it is not sufficiently supportive to fully elucidate the issue and additional well-designed studies are clearly needed.
关键词：insulin resistance; diabetes; metabolism; metabolic acidosis; glucose homeostasis; dietary acid load; western diet; acid–base insulin resistance ; diabetes ; metabolism ; metabolic acidosis ; glucose homeostasis ; dietary acid load ; western diet ; acid–base