文章基本信息

标题：Dermatitis Herpetiformis: A Common Extraintestinal Manifestation of Coeliac Disease
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作者：Timo Reunala ; Teea T. Salmi ; Kaisa Hervonen 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2018
卷号：10
期号：5
页码：602
DOI：10.3390/nu10050602
语种：English
出版社：MDPI Publishing
摘要：Dermatitis herpetiformis (DH) is a common extraintestinal manifestation of coeliac disease presenting with itchy papules and vesicles on the elbows, knees, and buttocks. Overt gastrointestinal symptoms are rare. Diagnosis of DH is easily confirmed by immunofluorescence biopsy showing pathognomonic granular immunoglobulin A (IgA) deposits in the papillary dermis. A valid hypothesis for the immunopathogenesis of DH is that it starts from latent or manifest coeliac disease in the gut and evolves into an immune complex deposition of high avidity IgA epidermal transglutaminase (TG3) antibodies, together with the TG3 enzyme, in the papillary dermis. The mean age at DH diagnosis has increased significantly in recent decades and presently is 40–50 years. The DH to coeliac disease prevalence ratio is 1:8 in Finland and the United Kingdom (U.K.). The annual DH incidence rate, currently 2.7 per 100,000 in Finland and 0.8 per 100,000 in the U.K., is decreasing, whereas the reverse is true for coeliac disease. The long-term prognosis of DH patients on a gluten-free diet is excellent, with the mortality rate being even lower than for the general population.
关键词：dermatitis herpetiformis; coeliac disease; prevalence; epidermal transglutaminase; gluten-free diet; long-term prognosis dermatitis herpetiformis ; coeliac disease ; prevalence ; epidermal transglutaminase ; gluten-free diet ; long-term prognosis