文章基本信息

标题：Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications
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作者：Jessica Wang ; Phoebe Um ; Barbra A. Dickerman 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2018
卷号：10
期号：5
页码：584
DOI：10.3390/nu10050584
语种：English
出版社：MDPI Publishing
摘要：Micronutrient deficiency and depression are major global health problems. Here, we first review recent empirical evidence of the association between several micronutrients—zinc, magnesium, selenium—and depression. We then present potential mechanisms of action and discuss the clinical implications for each micronutrient. Collectively, empirical evidence most strongly supports a positive association between zinc deficiency and the risk of depression and an inverse association between zinc supplementation and depressive symptoms. Less evidence is available regarding the relationship between magnesium and selenium deficiency and depression, and studies have been inconclusive. Potential mechanisms of action involve the HPA axis, glutamate homeostasis and inflammatory pathways. Findings support the importance of adequate consumption of micronutrients in the promotion of mental health, and the most common dietary sources for zinc and other micronutrients are provided. Future research is needed to prospectively investigate the association between micronutrient levels and depression as well as the safety and efficacy of micronutrient supplementation as an adjunct treatment for depression.
关键词：nutrition; micronutrient; diet; depression; zinc; magnesium; selenium; microbiota nutrition ; micronutrient ; diet ; depression ; zinc ; magnesium ; selenium ; microbiota