文章基本信息

标题：Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance
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作者：Kenneth D’Souza ; Geena V. Paramel ; Petra C. Kienesberger 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2018
卷号：10
期号：4
页码：399
DOI：10.3390/nu10040399
语种：English
出版社：MDPI Publishing
摘要：Although simple in structure, lysophosphatidic acid (LPA) is a potent bioactive lipid that profoundly influences cellular signaling and function upon binding to G protein-coupled receptors (LPA1-6). The majority of circulating LPA is produced by the secreted enzyme autotaxin (ATX). Alterations in LPA signaling, in conjunction with changes in autotaxin (ATX) expression and activity, have been implicated in metabolic and inflammatory disorders including obesity, insulin resistance, and cardiovascular disease. This review summarizes our current understanding of the sources and metabolism of LPA with focus on the influence of diet on circulating LPA. Furthermore, we explore how the ATX-LPA pathway impacts obesity and obesity-associated disorders, including impaired glucose homeostasis, insulin resistance, and cardiovascular disease.
关键词：lysophosphatidic acid; lysophospholipids; autotaxin; obesity; insulin resistance; adipocytes; cardiovascular disease; diet lysophosphatidic acid ; lysophospholipids ; autotaxin ; obesity ; insulin resistance ; adipocytes ; cardiovascular disease ; diet