文章基本信息

标题：Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health
本地全文：下载
作者：MCarment Martínez-Ballesta ; Ángel Gil-Izquierdo ; Cristina García-Viguera 等
期刊名称：Foods
电子版ISSN：2304-8158
出版年度：2018
卷号：7
期号：5
页码：72
DOI：10.3390/foods7050072
语种：English
出版社：MDPI Publishing
摘要：Nanotechnology is a field of research that has been stressed as a very valuable approach for the prevention and treatment of different human health disorders. This has been stressed as a delivery system for the therapeutic fight against an array of pathophysiological situations. Actually, industry has applied this technology in the search for new oral delivery alternatives obtained upon the modification of the solubility properties of bioactive compounds. Significant works have been made in the last years for testing the input that nanomaterials and nanoparticles provide for an array of pathophysiological situations. In this frame, this review addresses general questions concerning the extent to which nanoparticles offer alternatives that improve therapeutic value, while avoid toxicity, by releasing bioactive compounds specifically to target tissues affected by specific chemical and pathophysiological settings. In this regard, to date, the contribution of nanoparticles to protect encapsulated bioactive compounds from degradation as a result of gastrointestinal digestion and cellular metabolism, to enable their release in a controlled manner, enhancing biodistribution of bioactive compounds, and to allow them to target those tissues affected by biological disturbances has been demonstrated.
关键词：phytochemicals; nanoparticles; controlled release; improved functionality; health; smart-formulations phytochemicals ; nanoparticles ; controlled release ; improved functionality ; health ; smart-formulations