文章基本信息

标题：In Vitro and In Vivo SERS Biosensing for Disease Diagnosis
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作者：T. Joshua Moore ; Amber S. Moody ; Taylor D. Payne 等
期刊名称：Biosensors
电子版ISSN：2079-6374
出版年度：2018
卷号：8
期号：2
页码：46
DOI：10.3390/bios8020046
语种：English
出版社：MDPI Publishing
摘要：For many disease states, positive outcomes are directly linked to early diagnosis, where therapeutic intervention would be most effective. Recently, trends in disease diagnosis have focused on the development of label-free sensing techniques that are sensitive to low analyte concentrations found in the physiological environment. Surface-enhanced Raman spectroscopy (SERS) is a powerful vibrational spectroscopy that allows for label-free, highly sensitive, and selective detection of analytes through the amplification of localized electric fields on the surface of a plasmonic material when excited with monochromatic light. This results in enhancement of the Raman scattering signal, which allows for the detection of low concentration analytes, giving rise to the use of SERS as a diagnostic tool for disease. Here, we present a review of recent developments in the field of in vivo and in vitro SERS biosensing for a range of disease states including neurological disease, diabetes, cardiovascular disease, cancer, and viral disease.
关键词：SERS; biosensing; diagnostics; neurological disease; diabetes; cardiovascular disease; cancer; viral disease SERS ; biosensing ; diagnostics ; neurological disease ; diabetes ; cardiovascular disease ; cancer ; viral disease