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标题：Análogo de tejido conectivo injertado en recesiones gingivales inducidas en ratas Wistar
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作者：Karla Andreína Padrón Durán ; Lorena Dávila B. ; Daniela Andreina Olávez Cepeda 等
期刊名称：Avances en Biomedicina
印刷版ISSN：2244-7881
出版年度：2017
卷号：6
期号：1
页码：29-36
语种：English
出版社：Avances en Biomedicina
摘要：Mucogingival surgery aim is to prevent or treat anatomical, pathological and traumatic gingival defects, such as gingival recession, which cause functional aesthetic and biological difficulties. To treat them, it’s been developed, tissue substitutes obtained from gingival connective cells of the patient. The purpose of this study is to determine the effectiveness of an analogue connective tissue developed from human gingival fibroblasts, by the treatment of induced gingival recession. 24 male Wistar rats were selected, the periodontal clinical examination was carried out and gingival recession in right central upper incisor was induced; then after cicatrization it was made a flap to place the analog connective tissue graft obtained from a culture of human fibroblasts, in animals of group I, group II received a collagen scaffold without cells and group III were left without graft. The study results showed that 86.66% of the animals in group I had a 2mm insertion gain, while 13.3% won 1.5mm insertion. 86% of the animals of group II won 1mm insertion, and group III had not showed insertion gain, instead they remained with 2mm recession. In conclusion the gingival graft from a fibroblast cell culture can be considered as a viable alternative to achieve root coverage, and even increase the width of attached gingiva and thickness of periodontal biotype.