文章基本信息

标题：Prenylflavonoids from the Twigs of Artocarpus nigrifolius
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作者：Xi Liu ; Xiao-Dong Kuang ; Xiao-Ru He 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2018
卷号：66
期号：4
页码：434-438
DOI：10.1248/cpb.c17-00958
语种：English
出版社：The Pharmaceutical Society of Japan
摘要：Two new prenylated flavones, artocarnin A ( 2 ) and carpachromenol ( 12 ), together with 13 known prenylflavonoids ( 1 , 3 – 11 , 13–15 ) were isolated from the twigs of Artocarpus nigrifolius for the first time. Their structures were elucidated by high resolution-electrospray ionization (HR-ESI)-MS, NMR spectroscopic analysis, and in comparison with the reported data. Compounds 1 – 15 were evaluated for their antiproliferative effects against SiHa and SGC-7901 human cancer cell lines in vitro . The most active compound, eleocharin A ( 10 ), showed significant cytotoxicity on SiHa cells (IC₅₀=0.7±0.1 µM) and inhibitory activity against SGC-7901 cells (IC₅₀=8.3±0.2 µM) and could be considered as potential lead compound for further development of novel anti-tumor agents.
关键词：Artocarpus nigrifolius;prenylflavonoid;chalcone;flavone;cytotoxicity