文章基本信息

标题：Synthesis of Novel Benzimidazole-2-carboxamide Derivatives and in Vivo Antihyperlipidemic Activity Evaluation
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作者：Ghassan Abu Sheikha ; Majdi Mohammad Bkhaitan ; Hanin Kalloush 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2018
卷号：66
期号：4
页码：423-426
DOI：10.1248/cpb.c17-00908
语种：English
出版社：The Pharmaceutical Society of Japan
摘要：Hyperlipidemia is known as an elevation of plasma lipid components. It contributes significantly to atherosclerosis which is one of the most important causative factors in cardiovascular diseases. Agents that cause a dramatic decrease in serum lipid levels are of great value in the treatment of cardiovascular diseases. For this purpose, a new series of benzimidazole propyl carboxamide benzophenone derivatives have been synthesized ( 7 , 8 , and 9 ). These compounds were tested in vivo to evaluate their potential hypolipidemic activity using Triton WR-1339 induced hyperlipidemic rats. All the synthesized compounds have proved to be highly biologically active, with compound 9 being the most active derivative.
关键词：hyperlipidemia;Triton WR-1339;benzimidazole;low-density lipoprotein (LDL);cardiovascular disease