文章基本信息

标题：Collagen cross-linking: when and how? A review of the state of the art of the technique and new perspectives
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作者：Leonardo Mastropasqua
期刊名称：Eye and Vision
印刷版ISSN：2326-0254
出版年度：2015
卷号：2
期号：1
页码：19
DOI：10.1186/s40662-015-0030-6
语种：English
出版社：BioMed Central
摘要：Since the late 1990s corneal crosslinking (CXL) has been proposed as a new possibility to stop progression of keratoconus or secondary corneal ectasia, with the promising aim to prevent progressive visual loss due to the evolution of the pathology and to delay or avoid invasive surgical procedures such as corneal transplantation. The possibility of strengthening corneal tissue by means of a photochemical reaction of corneal collagen by the combined action of Riboflavin and ultraviolet A irradiation (UVA), radically modified the conservative management of progressive corneal ectasia. This is a review of the state of the art of CXL, reporting basic and clinical evidence. The paper describes basic principles, advantages and limits of different CXL techniques and possible future evolution of the procedure.
关键词：Keratoconus ; Ectasia ; Collagen cross-linking ; Transepithelial cross-linking ; Collagen corneal cross-linking epithelium off ; Collagen corneal cross-linking epithelium on ; Transepithelial cross-linking with iontophoresis