文章基本信息

标题：Reference ranges for rotational thromboelastometry in male Sprague Dawley rats
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作者：Mariana Vigiola Cruz ; Jenna N. Luker ; Bonnie C. Carney 等
期刊名称：Thrombosis Journal
印刷版ISSN：1477-9560
电子版ISSN：1477-9560
出版年度：2017
卷号：15
期号：1
页码：31
DOI：10.1186/s12959-017-0154-0
语种：English
出版社：BioMed Central
摘要：A functional coagulation assay was used to investigate the extrinsic pathway of coagulation on citrated whole blood samples from healthy adult male Sprague Dawley rats using the mini cup and pin system. Reference values for coagulation parameters from forty-three animals were calculated using data obtained from the ROTEM® delta hemostasis analyzer with the EXTEM test. The following ranges, presented as the 2.5–97.5 percentiles, were established: CT [18–77], CFT [20–80], α [73–86], MCF [53–70], and ML [1–22], along with others. These reference ranges can be used in future studies in rats to identify clinically significant coagulopathies.
关键词：Coagulation ; Sprague Dawley rat ; Thromboelastometry ; ROTEM ; Reference range