文章基本信息

标题：Antimicrobial studies of stem bark extract and their phytoconstituent from Semecarpus anacardium L.
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作者：Venkatesh ; Krishna V ; Jayabaskaran C 等
期刊名称：International Journal of Fundamental and Applied Sciences
印刷版ISSN：2278-1404
出版年度：2018
卷号：7
期号：1
页码：2-9
出版社：BioMedAsia
摘要：Background & Objective: To investigate the antimicrobial properties of stem bark extract of S. anacardium and their phytoconstituent using agar well diffusion and in silico docking methods. Methodology: In vitro antibacterial activity of petroleum ether, chloroform, methanol stem bark extract of S. anacardium was screened against both gram negative and gram positive bacteria. Results: The methanol extract of stem bark and amentoflavone, a bioactive compound showed significant antibacterial activity against Klebsiella pneumonia and antifungal activity against Candida albicans. In silico docking of amentoflavone with bacterial glucosamine-6-phosphate synthase and three fungal targets, mevalonate-5-diphosphate decarboxylase (1FI4), Sec3 - Rho1 complexes (3A58), Kre2p/Mnt1pa1, 2-mannosyltransferase (1S4N) showed significant inhibition with minimum binding energy, when compare to standard drug ciprofloxacin and amphotericin B. Conclusion: This study clearly showed that the amentoflavone used as broad spectrum of antimicrobial drug.
关键词：Antimicrobial activity; Klebsiella pneumonia; Ciprofloxacin; Amphotericin B; Docking studies