文章基本信息

标题：Differences in the expression of selected genes associated with cell stress response in a PTSD patient and in healthy individuals – a case study
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作者：Anna Rasmus ; Paweł Półrola ; Jolanta Góral-Półrola 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2017
卷号：24
期号：2
页码：332-337
DOI：10.26444/aaem/74711
出版社：Institute of Agricultural Medicine in Lublin
摘要：Objective. The aim of the study was determination of the level in expression genes associated with cell stress response ina patient with PTSD.Case study. A 57-year-old PTSD patient, A.P., was the subject of the study. Blood samples were taken from the ulnar veinto assess the relative expression of the tested genes in leukocytes via a quantitative reverse transcription polymerase chainreaction (qRT-PCR).Results. A considerably decreased level in the expression HSF-1, NF-kB, Hif-1 and IL6 m-RNA was observed in the patientwhen compared to the control group. A low expression in HSPA1A, HSPB1, IL10 and CRP m-RNA compared with the controlgroup was also noted.Conclusion. It is possible that the lower level of transcriptional factors: HSF-1, NF-kB and Hif-1 as well as IL6 m-RNA may beassociated with the effect of the PTSD patient’s treatment.
关键词：cell stress; PTSD patient; expression of selected genes; healthy individuals