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标题：Predictors of Hepatitis B Surface Antigen Titers two decades after vaccination in a cohort of students and post-graduates of the Medical School at the University of Palermo, Italy
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作者：MG Verso ; N Lo Cascio ; E Noto Laddeca 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2017
卷号：24
期号：2
页码：303-306
DOI：10.26444/aaem/74716
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. The introduction of a vaccine against hepatitis B virus (HBV) for newborn babies in Italy in1991, extended to 12-year-old children for the first 12 years of application, has been a major achievement in terms of theprevention of HBV infection. The objective of this study was to analyse the long-term immunogenicity and effectivenessof HBV vaccination among healthcare students with different working seniorities.Materials and method. A cross-sectional observational study of undergraduate and postgraduate students attendingthe Medical School of the University of Palermo was conducted from January 2014 – July 2016. HBV serum markers wereperformed with commercial chemiluminescence assays. Categorical variables were analyzed using the chi-square test(Mantel–Haenszel), whereas means were compared by using the Student’s t test. Adjusted odds ratios (ORs) and 95%confidence intervals (CIs) were also calculated by a multivariable logistic regression, using a model constructed to examinepredictors of anti-HBs titer above 10 mIU/mL, assumed as protective.Results. Of the 2,114 subjects evaluated – all vaccinated at infancy or at the age of 12 years and were HBsAg/anti-HBcnegative – 806 (38.1%) had an anti-HBs titre <10 IU/L. The latter were younger, more likely to be attending a healthcareprofession school (i.e., nursing and midwifery), than a medical postgraduate level school, and more likely to have beenvaccinated in infancy (p <0.001, 95% CI 2.63–5.26, adjusted OR 3.70).Conclusion. The results of the study suggest that assessment of HBV serum markers in workers potentially exposed tohospital infections is useful for identifying small numbers of unvaccinated subjects, or vaccinated subjects with low antibodytitre, all of whom should be referred to a booster series of vaccinations.
关键词：HBV infection; HBV vaccination; Anti-HBs titre; Healthcare students; postgraduate medical students