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标题：Levels of renalase and advanced oxidation protein products with regard to catecholamines in haemodialysed patients
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作者：Marcin Dziedzic ; Ewelina Orłowska ; Beata Petkowicz 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2017
卷号：24
期号：3
页码：453-458
DOI：10.5604/12321966.1233567
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction. The main mediators of the sympathetic nervous system in the effectors part are catecholamines (CA). Anincreased sympathetic nerve activity observed in chronic kidney disease (CKD), is due to a raised level of CA in plasma.Renalase is a protein secreted by the kidneys, composed of 342 amino acids, which is able to metabolize the circulatingCA and possibly play an important role in the regulation of sympathetic tone and blood pressure. Also, oxidative stress,defined as a disruption of the equilibrium between the generation of oxidants, is a crucial factor in the development of theinflammatory syndrome associated with CKD. The advanced oxidation protein products (AOPP) represent exquisite markersof phagocyte-derived oxidative stress.Objective. The aim of the study was to investigate the concentration of renalase and explore the associations betweenAOPP with regards to CA in haemodialysis (HD) patients.Materials and method. The study was conducted among 50 residents of the municipality and neighbouring villages inthe province of Lublin, central-eastern Poland.Results. In the studied patients, it was found that an average concentration of renalase was 44.8 ± 6.5 μg/mL, whereas ofAOPP plasma levels – 57.5 ± 21.5 μmol/L. The results demonstrated the correlation between levels of renalase and AOPP inthe HD patients. Indeed, elevated levels of renalase and AOPP in HD may be due to the presence of uremic toxins in blood.The concentration of urea affects the plasma concentrations of AOPP and renalase causing a direct relationship betweenrenalase and AOPP. However, there is no clear relationship between renalase and circulating catecholamines in HD patients.
关键词：renalase; advanced oxidation protein products; catecholamines; haemodialysis