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标题：Anti-thyroidal peroxidase antibodies are associated with thyrotropin levels in hypothyroid patients and in euthyroid individuals
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作者：Barbara Bromińska ; Gabriel Bromiński ; Maciej Owecki 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2017
卷号：24
期号：3
页码：431-434
DOI：10.5604/12321966.1232090
出版社：Institute of Agricultural Medicine in Lublin
摘要：Objective. The study was designed to evaluate the relationship between thyroid antibodies and gland dysfunction, withthe aim of finding a clinically useful threshold value of thyreoperoxidase antibodies, which could prove to be predictivefor thyroid failure.Materials and method. The study was conducted on 99 women, ages ranging from 18–91 years (mean age: 45.5 ±17.0),were treated as outpatients in the Department of Endocrinology, Metabolism and Internal Medicine. Analysis of serumsamples for TSH concentration and anti-TPO titers was conducted.Results. The most common disorder was hypothyroidism. Anti-TPO titers above reference range values were observed in 35patients (35.4%): 21 (60%) were hypothyroid and 11 (31.4 %) were euthyroid. The anti-TPO and TSH serum levels correlatedboth in patients with high thyroid antibody titers, and in the anti-TPO negative groups. To find the threshold value of anti-TPO that would help predict hypothyroidism, receiver operating curves were used. With this approach, TPO antibody titersover 17 IU/ml indicated hypothyroidism with a 90% sensitivity and 75% sensibility.Conclusion. It can be postulated that the cutoff values of anti-TPO in the general population should be decreased in orderto improve autoimmune thyroid disorder screening. Obviously, using that margin may lead initially to the detection of somefalse positive subjects. However, with lower cut-off values, more patients can be enrolled into thyroid follow-up groups. Inthis way, many people could avoid complications of undiagnosed, insidious thyroid failure.
关键词：anti-TPO; autoimmunity; hypothyroidism; euthyroidism; TSH; thyreoperoxidase