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标题：Gut microbiome as a biomarker of cardiometabolic disorders
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作者：Anna Gózd-Barszczewska ; Maria Kozioł-Montewka ; Piotr Barszczewski 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2017
卷号：24
期号：3
页码：416-422
DOI：10.26444/aaem/75456
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. Cardiovascular diseases are the leading cause of death in Europe and worldwide. One of themost important risk factors for atherosclerosis are lipid metabolism disorders, in particular hipercholesterolaemia. The aimof the study was to determine the correlation between gut microbiota composition and atherosclerosis risk factors, so inorder that it might be used as a biomarker for coronary artery disease diagnosis.Material and method. The study involved middle-aged men in eastern Poland with central obesity (n=20), subjects withatherosclerosis (n=15) and those with no cardiovascular diseases (n=5). The gut microbiota composition was determinedusing tag-encoded 16S rRNA gene using Illuminal MiSeq. Data were analyzed with the use of t-test.Results. Firmicutes (49.26%) and Bacteroidetes (44.46%) were the dominant Phyla in the middle-aged men in eastern Poland.Subjects with improper levels of total cholesterol were enriched in Prevotella (p=0.03) and decreased level of Clostridium(p=0.02). They also showed a falling tendency in Faecalibacterium (p=0.07). An upward trend was observed in Prevotella(p=0.07) in subjects with improper LDL-C values.Conclusions. The study showed that intestinal microbiome is likely to play a role in the pathogenesis of atherosclerosisthrough its role in lipid metabolism. Bacterial genera of particular importance were Prevotella, Bacteroides, Clostridium,Faecalibacterium. However, further studies involving larger groups of subjects are required to confirm these observations.
关键词：gut microbiota; atherosclerosis; lipid disorders; microbiome; cardiovascular diseases